2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

Related Products

PDF 3.95 MB

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W037282
    O-Desmethyl quinidine
    		99.05%
    O-Desmethyl quinidine (Cupreidine) is an orally active metabolite of Quinine (HY-D0143). O-Desmethyl quinidine reduces frequency of cramps in rats with spinal cord injury and shows low blood toxicity.
    O-Desmethyl quinidine
  • HY-141626S
    6β-Hydroxytestosterone-d7
    6β-Hydroxytestosterone-d7 is a deuterated labeled 6β-Hydroxytestosterone. 6β-Hydroxytestosterone is a major metabolite of Testosterone.
    6β-Hydroxytestosterone-d<sub>7</sub>
  • HY-126303
    GS-443902
    		99.87%
    GS-443902 (GS-441524 triphosphate) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir.
    GS-443902
  • HY-138627
    AST5902
    AST5902 is the active metabolite of Firmonertinib (HY-112870) (EGFR inhibitor). AST5902 has antineoplastic activity.
    AST5902
  • HY-136576
    RP101075
    		99.19%
    RP101075, an active metabolite of Ozanimod, is a potent, orally active S1PR (sphingosine-1-phosphate receptor 1) agonist, with an EC50 of 0.27 nM. RP101075 displays >100-fold selectivity over S1PR5 (EC50=5.9 nM) and >10000-fold over S1PR 2, 3, and 4. RP101075 displays superior cardiovascular safety profile.
    RP101075
  • HY-B1417S
    Nortriptyline-d3 hydrochloride
    		99.75%
    Nortriptyline-d3 (hydrochloride) is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression.
    Nortriptyline-d<sub>3</sub> hydrochloride
  • HY-66008S
    N-Acetyl mesalazine-d3
    		98.0%
    N-Acetyl mesalazine-d3 (N-Acetyl-5-aminosalicylic acid-d3) is the deuterium labeled N-Acetyl mesalazine (HY-66008). N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the primary intestinal metabolite of 5-Aminosalicylic Acid (HY-15027) and serves as a biomarker for evaluating the efficacy of 5-Aminosalicylic Acid (HY-15027). N-Acetyl mesalazine can scavenge free radicals, reduce DNA base hydroxylation, and ameliorate mucosal inflammation. N-Acetyl mesalazine can be used in the study of diseases such as colitis and colon cancer.
    N-Acetyl mesalazine-d<sub>3</sub>
  • HY-135391S
    Ezetimibe phenoxy glucuronide-d4
    Ezetimibe phenoxy glucuronide-d4 is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity. Ezetimibe is a potent cholesterol absorption inhibitor.
    Ezetimibe phenoxy glucuronide-d<sub>4</sub>
  • HY-131267
    Febuxostat sec-butoxy acid
    Febuxostat sec-butoxy acid is an impurity of Febuxostat (HY-14268). Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat sec-butoxy acid
  • HY-113629
    2-Keto-D-Glucose
    		98.41%
    2-Keto-D-Glucose (D-Glucosone) is a key intermediate in a secondary metabolic pathway leading to the antibiotic Cortalcerone. 2-Keto-D-Glucose is also an intermediate in the conversion of D-glucose into D-fructose. 2-Keto-D-Glucose is found in various natural sources, including fungi, algae, and shellfish.
    2-Keto-D-Glucose
  • HY-133694S
    2-Aminoflubendazole-13C6
    		99.8%
    2-Aminoflubendazole-13C6 is the 13C6 labeled 2-Aminoflubendazole. 2-Aminoflubendazole is the metabolite of Benzimidazoles. Benzimidazoles (BZ) are a class of agents with activities against fungi, protozoa, and helminthes.
    2-Aminoflubendazole-<sup>13</sup>C<sub>6</sub>
  • HY-B2124
    10,11-Dihydrocarbamazepine
    10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy.
    10,11-Dihydrocarbamazepine
  • HY-133770
    Seco Rapamycin ethyl ester
    Seco Rapamycin ethyl ester is an open-ring metabolite of Rapamycin derivative. Seco-rapamycin is reported not to affect the mTOR function.
    Seco Rapamycin ethyl ester
  • HY-N7143R
    Monobutyl phthalate (Standard)
    Monobutyl phthalate (Standard) is the analytical standard of Monobutyl phthalate. This product is intended for research and analytical applications. Monobutyl phthalate, a major metabolite of dibutyl phthalate (DBP), possesses antiandrogenic effects. Monobutyl phthalate is an embryotoxicant.
    Monobutyl phthalate (Standard)
  • HY-113456S
    Leukotriene D4-d5
    		98.4%
    Leukotriene D4-d5 is the deuterium labeled Leukotriene D4. Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.
    Leukotriene D4-d<sub>5</sub>
  • HY-G0002A
    Lurasidone metabolite 14326 hydrochloride
    		Chemical 99.42%
    Lurasidone metabolite 14326 (hydrochloride) is an active metabolite of the atypical antipsychotic Lurasidone.
    Lurasidone metabolite 14326 hydrochloride
  • HY-12778S
    N-Demethyl Ivabradine-d6 hydrochloride
    		98.0%
    N-Demethyl Ivabradine-d6 (hydrochloride) is the deuterium labeled N-Demethyl Ivabradine, which is a metabolite of Ivabradine.
    N-Demethyl Ivabradine-d<sub>6</sub> hydrochloride
  • HY-122439
    Lovastatin acid
    Lovastatin acid (Mevinolinic acid), an active metabolite of Lovastatin, is a potent competitive HMG-CoA reductase inhibitor with a Ki of 0.6 nM.
    Lovastatin acid
  • HY-103687
    Abiraterone metabolite 1
    		99.59%
    Abiraterone metabolite 1 is a 5β-reduced metabolite of abiraterone. Abiraterone, a steroidal agent, inhibits CYP17A1, blocks androgen synthesis and prolongs survival in prostate cancer.
    Abiraterone metabolite 1
  • HY-12769
    Mebeverine acid
    		99.70%
    Mebeverine acid (Mebeverine metabolite Mebeverine acid) is a secondary metabolite of Mebeverine. Mebeverine is an antispasmodic agent. Mebeverine acid is a valuable marker of oral exposure to Mebeverine.
    Mebeverine acid
Cat. No. Product Name / Synonyms Application Reactivity