2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1103
    Hydroxyhexamide
    		99.60%
    Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agents.
    Hydroxyhexamide
  • HY-116909
    O-Methylsterigmatocystin
    		99.3%
    O-Methylsterigmatocystin is a metabolite in Aspergillus flavus and Aspergillus parasiticus.
    O-Methylsterigmatocystin
  • HY-171459
    LEQ803
    		99.37%
    LEQ803 (N-Desmethyl Ribociclib) is a drug metabolite of the CDK4/6 inhibitor Ribociclib (HY-15777), which is produced through metabolism by CYP3A4. LEQ803 has potential application value in the field of oncology.
    LEQ803
  • HY-156836A
    Tyramine O-sulfate sodium
    Tyramine O-sulfate (Tyramine sulfate) sodium is a metabolite of Tyramine (HY-W007606) in urinary. Tyramine O-sulfate sodium can be used as a marker for melancholia.
    Tyramine O-sulfate sodium
  • HY-G0004
    Acetaminophen metabolite 3-hydroxy-acetaminophen
    		99.76%
    Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen) is a non-toxic metabolite and antioxidant of acetaminophen (HY-66005) with free radical scavenging activity. Acetaminophen metabolite 3-hydroxy-acetaminophen can reduce oxidative damage by exerting electron donation ability and antioxidant activity through phenolic hydroxyl groups. 3-hydroxy-acetaminophen can be used to study the toxicity mechanism and drug metabolism of acetaminophen.
    Acetaminophen metabolite 3-hydroxy-acetaminophen
  • HY-126857S
    5-Hydroxy Omeprazole-d3
    		98.27%
    5-Hydroxy Omeprazole-d3 is deuterium labeled 5-Hydroxyomeprazole.
    5-Hydroxy Omeprazole-d<sub>3</sub>
  • HY-17528
    Cyhalofop
    Cyhalofop (Cyhalofop acid), the primary metabolite of Cyhalofop-butyl (HY-B0861) in susceptible grasses, is the herbicidally active metabolite. Cyhalofop-butyl is an aryloxyphenoxypropionate post-emergence herbicide widely used around the world in agriculture.
    Cyhalofop
  • HY-W338852
    Gentisuric acid
    		99.65%
    Gentisuric acid, a metabolite of Aspirin (HY-14654), is a substrate of α-amidating monooxygenase (PAM). Gentisuric acid prevents DNA-damage by Mitomycin C (HY-13316).
    Gentisuric acid
  • HY-12767
    Carvedilol metabolite 4-Hydroxyphenyl Carvedilol
    		98.59%
    4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol, which is a nonselective beta blocker/alpha-1 blocker.
    Carvedilol metabolite 4-Hydroxyphenyl Carvedilol
  • HY-W585952
    Salicylic acid 2-O-β-D-glucoside
    Salicylic acid 2-O-β-D-glucoside (SA-2-O-β-D-glucoside) is the predominant glycosylated metabolite of Salicylic Acid (HY-B0167).
    Salicylic acid 2-O-β-D-glucoside
  • HY-I0169
    (R)-Amino-N-benzyl-3-methoxypropionamide
    		99.95%
    (R)-Amino-N-benzyl-3-methoxypropionamide is a stable intermediate of Lacosamide (an antiepileptic drug).
    (R)-Amino-N-benzyl-3-methoxypropionamide
  • HY-W009713
    3,4,5-Trimethoxyphenylacetic acid
    		99.70%
    3,4,5-Trimethoxyphenylacetic acid is a metabolite of Mescaline.
    3,4,5-Trimethoxyphenylacetic acid
  • HY-130189R
    S-Phenylmercapturic acid (Standard)
    S-Phenylmercapturic acid (Standard) is the analytical standard of S-Phenylmercapturic acid. This product is intended for research and analytical applications. S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay.
    S-Phenylmercapturic acid (Standard)
  • HY-W037282
    O-Desmethyl quinidine
    		99.05%
    O-Desmethyl quinidine (Cupreidine) is an orally active metabolite of Quinine (HY-D0143). O-Desmethyl quinidine reduces frequency of cramps in rats with spinal cord injury and shows low blood toxicity.
    O-Desmethyl quinidine
  • HY-108229S
    6β-Naltrexol-d3
    		99.72%
    6β-Naltrexol-d3 (6β-Hydroxynaltrexone-d3) is deuterium labeled 6β-Naltrexol. 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit.
    6β-Naltrexol-d<sub>3</sub>
  • HY-126303
    GS-443902
    		99.87%
    GS-443902 (GS-441524 triphosphate) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir.
    GS-443902
  • HY-138627
    AST5902
    AST5902 is the active metabolite of Firmonertinib (HY-112870) (EGFR inhibitor). AST5902 has antineoplastic activity.
    AST5902
  • HY-66008S
    N-Acetyl mesalazine-d3
    		98.0%
    N-Acetyl mesalazine-d3 (N-Acetyl-5-aminosalicylic acid-d3) is the deuterium labeled N-Acetyl mesalazine (HY-66008). N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the primary intestinal metabolite of 5-Aminosalicylic Acid (HY-15027) and serves as a biomarker for evaluating the efficacy of 5-Aminosalicylic Acid (HY-15027). N-Acetyl mesalazine can scavenge free radicals, reduce DNA base hydroxylation, and ameliorate mucosal inflammation. N-Acetyl mesalazine can be used in the study of diseases such as colitis and colon cancer.
    N-Acetyl mesalazine-d<sub>3</sub>
  • HY-10873S
    N-Desethyl Sunitinib-d5
    N-Desethyl Sunitinib-d5 is the deuterium labeled N-Desethyl Sunitinib. N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively.
    N-Desethyl Sunitinib-d<sub>5</sub>
  • HY-131964
    Imidacloprid-urea
    		99.86%
    Imidacloprid-urea is a metabolite of Imidacloprid (HY-B0838). Imidacloprid is an effective and widely used neonicotinoid pesticide to control pests of cereals, vegetables, tea and cotton. Imidacloprid-urea can occupy or block adsorption sites of imidacloprid on soil, potentially affecting the fate, transport, and bioavailability of imidacloprid in the environment.
    Imidacloprid-urea
Cat. No. Product Name / Synonyms Application Reactivity